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Acid Blockers for Constant Heartburn and Acid Reflux These drugs work by blocking just how much stomach acid you produce. Not as fast-acting as antacids, these acid blockers stay longer and often will be efficient for a lot of hours at a time, says the AGA. Over-the-counter acid blockers include Axid, Pepcid, Tagamet, and Zantac. These brands are also available in prescription strength whenever the more mild forms don't bring enough relief. acid reflux disease These drugs work by blocking a variety of histamine developed by your stomach, which experts claim blocks acid production. These histamine blockers will be taken twice daily, 30 to 60 minutes before eating for being most beneficial. They're best used as a form of safety measure, instead of sudden, fast relief of symptoms.